There are two common methods for manufacturing NMN:

• Chemical synthesis: Labour-intensive and expensive, this method creates a high yield and allows for careful control of starting materials, though none are sourced from biological systems. It uses environmentally-damaging solvents and impurities and byproducts in the finished product can be difficult to remove.
• Enzymatic synthesis: This option is expensive, but produces a higher yield and very high purity. It’s considered a green preparation method for the production of NMN.

Motogene's BetAging NMN is made of Enzymatic synthesis. Our products are tested with Microbiology Analysis and Heavy Metal Analysis (lead, mercury, Arsenic), carried out by third party labs to ensure consumption safety. A high quality NMN is the reason most of our consumers experience their first effect as quickly as 14 days of consuming Motogene NMN.

The first human safety trial of NMN in humans was published in 2019 and showed that a single dose of up to 500mg was tolerable.NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. However if you experience nausea, diarrhoea, flushing, stomach discomfort and indigestion. You can start with low dose of 250mg and gradually increase dosage after a week.

The minimum dose of NMN is 250mg per day, any amount lesser than 250mg has proven to be no effect according to research from most scientists. It takes about 9 days for NMN to build up the NAD+ reservoir. Take your NMN in the morning on an empty stomach to sync your NMN consumption with your Circardian rhythms (our body's inner clock). If you're younger than 35, you can start with 250mg/day and after 1-2weeks increase to 500mg to see what feels better. If you're older than 35, start with 500mg/day, then increase to 1g to see what feels better.

Our NMN products boast an exceptional level of purity, reaching 99%. NMN is sourced from natural ingredients, and due to the extraction process, a small fraction, 1%, remains as NAM (Nicotinamide), a type of vitamin B3 and an NAD+ precursor. Notably, NAM can still undergo conversion into NMN within your body, further elevating your NAD+ levels.

Yes. Dr David Sinclair takes NAD+ booster such as NMN when he arrives in a new timezone. NAD+ helps boost the activity of your SIRTUIN genes, which drive the circadian rhythms, your body's master "clock." Altered NAD+ levels may be the root cause of jet lag and the overall loss of energy we experience as we age. Circadian clock regulate processes such as

• Sleep/wake cycles
• Hormonal activity
• Body temperature rhythm
  
• Eating and digesting

Yes, we are fully GMP compliant. We are also Halal certified by Jakim as well as HACCP, MeSTI and ISO. Our stringent quality standards are why we have over 80% return customer.

NMN is a naturally occurring compound within the human body and has been confirmed as safe for human consumption through a Japanese human trial conducted in 2020.

Several health studies propose that adding different NMN doses to your diet could raise NAD+ levels, enhance physical capabilities, and positively impact specific aspects of metabolic well-being, such as insulin sensitivity. Nevertheless, the available human studies examining the potential advantages, potential side effects, and safety of NMN supplements remain relatively scarce.

Research conducted by the Washington University School of Medicine in St. Louis demonstrated that the daily intake of 250 mg of NMN orally over a 10-week period enhances muscle insulin sensitivity and structure in older women.

In recent years, NMN has garnered significant attention, particularly following the release of Harvard professor David Sinclair's 2019 book, 'Lifespan.' Professor Sinclair openly discusses his personal use of NMN and highlights various cases of individuals who have reported positive effects after taking NMN.

Within his book, Professor Sinclair delves into the concept that elevating NAD+ levels through NMN supplementation extends the lifespan of various organisms, including yeast, worms, and mice. In experimental subjects, NMN administration has demonstrated beneficial impacts on age-related concerns such as skin health, energy levels, and cognitive well-being. Nevertheless, human efficacy trials remain in their early stages.

While a limited number of human trials have been conducted, several are currently underway. NMN has been established as safe for human use and effectively raises NAD+ levels. Recent research also indicates favourable outcomes regarding exercise endurance and insulin sensitivity.

A 2023 study found that consuming 900 milligrams of NMN through oral administration is generally considered safe and well-received among adults. Incorporating NMN supplements into your morning routine can potentially energise your day, as NMN plays a crucial role in ATP (adenosine triphosphate) production, a fundamental process for generating cellular energy.

As individuals age, NAD+ levels naturally decrease, prompting many to explore NMN supplementation to elevate these levels. The body converts NMN into NAD+ and deploys it for various physiological functions. Enhancing these levels makes it possible to effectively rewind the biological clock and potentially decelerate the pace of aging.

The human body naturally generates NMN, so discontinuing NMN supplementation carries no adverse consequences. NAD+ levels would merely revert to their pre-supplement state. However, retaining the potential advantages, such as enhanced longevity, blood sugar regulation, and cognitive function, that NMN supplementation can offer might prove challenging.

Taking multiple supplements alongside NMN should generally pose no concerns, as there are no documented adverse interactions with other supplements. NMN is a naturally occurring compound in the human body and is derived from vitamin B3. However, to thoroughly evaluate the compatibility of specific supplements with NMN, we strongly advise consulting a healthcare professional before initiating any new regimen.